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<span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Dear all,<br>
<br>
We are happy to announce that the following paper is now published in Developmental & Comparative Immunology.<br></span></font></span><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">

We investigated the innate immune response of bottlenose dolphins against apicomplexan parasite <i>Toxoplasma gondii</i>. <br></span></font></span></div><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"><br></span></font></span></div><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"><br></span></font></span></div><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"></span></font></span></div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Michelle Imlau, Iván Conejeros, Tamara Muñoz-Caro, Ershun Zhou, Ulrich Gärtner, Kerstin Ternes, Anja Taubert, Carlos Hermosilla,<br>Dolphin-derived NETosis results in rapid <i>Toxoplasma gondii </i>tachyzoite ensnarement and different phenotypes of NETs, Developmental & Comparative Immunology, Volume 103, 2020.<br>
<br>
*Abstract*<br>

</span></font></span><div id="gmail-abssec0010"><p id="gmail-abspara0010"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"><em>Toxoplasma gondii</em> is a
 cosmopolitan zoonotic parasite and nowadays considered as an emerging 
neozoan pathogen in the marine environment. Cetacean innate immune 
reactions against <em>T. gondii</em> stages have not yet been investigated. Thus, <em>T. gondii</em> tachyzoites were utilized to trigger neutrophil extracellular traps (NETs) in bottlenose dolphin (<em>Tursiops truncatus</em>) polymorphonuclear neutrophils (PMN). Scanning electron microscopy unveiled <em>T. gondii</em>
 tachyzoites as potent and rapid inducers of cetacean-derived NETosis. 
Co-localization of extracellular chromatin with global histones, 
granulocytic myeloperoxidase and neutrophil elastase confirmed classical
 characteristics of NETosis. Interestingly, different phenotypes of NETs
 were induced by tachyzoites resulting in spread, diffuse and aggregated
 NET formation and moreover, ‘anchored’ and ‘cell free’ NETosis was also
 detected.</span></font></span></p><p id="gmail-abspara0015"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Current data indicate that 
cetacean-derived NETosis might represent an early, ancient and 
well-conserved host innate defense mechanism that not only acts against <em>T. gondii</em> but might also occur in response to other closely related emerging apicomplexan parasites affecting marine cetaceans.</span></font></span></p></div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">


</span></font></span><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">
*Link to full text*: <a href="https://www.sciencedirect.com/science/article/pii/S0145305X19302964?utm_campaign=STMJ_75273_AUTH_SERV_PPUB&utm_medium=email&utm_dgroup=Email1Publishing&utm_acid=-800202876&SIS_ID=-1&dgcid=STMJ_75273_AUTH_SERV_PPUB&CMX_ID=&utm_in=DM601392&utm_source=AC_30">https://www.sciencedirect.com/science/article</a></span></font></span></div><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"><br></span></font></span></div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">

Best regards,<br>
<br></span></font></span><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Michelle</span></font></span></div><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"><br></span></font></span></div><div><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">



















</span></font></span><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Michelle Imlau, med. vet.<span></span></span></font></span></p><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">

</span></font></span><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"><span></span></span></font></span></p><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">

</span></font></span><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Pathology
Resident<span></span></span></font></span></p><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">

</span></font></span><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">Centre for
Fish and Wildlife Health (FIWI)<span></span></span></font></span></p><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif">

</span></font></span><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt"><font size="2"><span style="font-family:arial,sans-serif"><span style="color:rgb(31,73,125)" lang="EN-US"><span style="color:rgb(0,0,0)">Vetsuisse
Faculty, University of Bern</span></span></span></font></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:"Calibri",sans-serif"><font size="2"><span style="font-family:arial,sans-serif"><a href="mailto:michelle.imlau@vetsuisse.unibe.ch">michelle.imlau@vetsuisse.unibe.ch</a></span></font><br><span style="font-size:10pt;color:rgb(31,73,125)" lang="EN-US"><span style="color:rgb(0,0,0)"><font size="2"><span style="font-family:arial,sans-serif"></span></font></span><span></span></span></p>





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