[MARMAM] New publication: A Multi-Matrix Metabolomic Approach in Ringed Seals and Beluga Whales to Evaluate Contaminant and Climate-Related Stressors

Antoine Simond antoine.simond at gmail.com
Wed Aug 31 09:21:37 PDT 2022


Hello everyone,

My co-authors and I are pleased to announce and share our recent paper
titled:

*A Multi-Matrix Metabolomic Approach in Ringed Seals and Beluga Whales to
Evaluate Contaminant and Climate-Related Stressors*

Simond, A.E., Noël, M., Loseto, L., Houde, M., Kirk, J., Elliott, A., and
Brown, T.M.

*Abstract*
As a high trophic-level species, ringed seals (*Pusa hispida*) and beluga
whales (*Delphinapterus leucas*) are particularly vulnerable to elevated
concentrations of biomagnifying contaminants, such as polychlorinated
biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and mercury (Hg).
These species also face climate-change-related impacts which are leading to
alterations in their diet and associated contaminant exposure. The
metabolomic profile of marine mammal tissues and how it changes to
environmental stressors is poorly understood. This study characterizes the
profiles of 235 metabolites across plasma, liver, and inner and outer
blubber in adult ringed seals and beluga whales and assesses how these
profiles change as a consequence of contaminants and dietary changes. In
both species, inner and outer blubber were characterized by a greater
proportion of lipid classes, whereas the dominant metabolites in liver and
plasma were amino acids, carbohydrates, biogenic amines and
lysophosphatidylcholines. Several metabolite profiles in ringed seal plasma
correlated with δ13C, while metabolite profiles in blubber were affected by
hexabromobenzene in ringed seals and PBDEs and Hg in belugas. This study
provides insight into inter-matrix similarities and differences across
tissues and suggests that plasma and liver are more suitable for studying
changes in diet, whereas liver and blubber are more suitable for studying
the impacts of contaminants.

The paper is open access and can be downloaded here:
https://www.mdpi.com/2218-1989/12/9/813

Please contact me at asimond at sfu.ca if you would like a copy of the
manuscript or if you have any questions.

Best regards,

Antoine Simond
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