[MARMAM] New publication: systematic determination of Herpesvirus

Ignacio Vargas Castro ignavarg at ucm.es
Thu Oct 28 08:20:30 PDT 2021


Dear MARMAM community,

My co-authors and I are pleased to announce a new publication that arises
from our research on cetacean herpesvirus in cetaceans stranded on the
Spanish Mediterranean coast between 2010 and 2013.

Vargas‐Castro, I.; Melero, M.; Crespo‐Picazo, J.L.; Jiménez, M.A.; Sierra,
E.; Rubio‐Guerri, C.; Arbelo, M.; Fernández, A.; García‐Párraga, D.;
Sánchez‐Vizcaíno, J.M. *Systematic Determination of Herpesvirus in
Free‐Ranging Cetaceans Stranded in the Western Mediterranean: Tissue
Tropism and Associated Lesions.* Viruses 2021, 13, 2180.
https://doi.org/10.3390/ v13112180

*Abstract*:  *The monitoring of herpesvirus infection provides useful
information when assessing marine mammals’ health.  This paper shows the
prevalence of herpesvirus infection (80.85%) in 47 ce-taceans stranded on
the coast of the Valencian Community, Spain. Of the 966 tissues evaluated,
121 tested positive when employing nested-PCR (12.53%). The largest
proportion of herpesvi-rus-positive tissue samples was in the reproductive
system, nervous system and tegument. Herpesvirus was more prevalent in
females, juveniles and calves. More than half the DNA PCR positive tissues
contained herpesvirus RNA, indicating the presence of actively replicating
virus. This RNA was most frequently found in neonates. Fourteen unique
sequences were identi-fied. Most amplified sequences belonged to the
Gammaherpesvirinae subfamily, but a greater variation was found in
Alphaherpesvirinae sequences. This is the first report of systematic
herpesvirus DNA and RNA determination in free-ranging cetaceans. Nine
(19.14%) were in-fected with cetacean morbillivirus and all of them (100%)
were coinfected with herpesvirus. Lesions similar to those caused by
herpesvirus in other species were observed, mainly in the skin, upper
digestive tract, genitalia and central nervous system. Other lesions were
also at-tributable to concomitant etiologies or were nonspecific. It is
necessary to investigate the pos-sible role of herpesvirus infection in
those cases.*

The article is free for download at the link:
https://www.mdpi.com/1999-4915/13/11/2180
or could request in researchgate or to me at: ignavarg at ucm.es

Sincerely,



*Ignacio Vargas Castro*

DVM, PhD Student

Viral Immunology and Preventive Medicine Unit (SUAT)
VISAVET Health Surveillance Centre & Animal Health Department
Universidad Complutense Madrid

Av. Puerta de Hierro, s/n. 28040 Madrid.
Spainignavarg at ucm.eswww.sanidadanimal.info
<https://www.sanidadanimal.info/en/>

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