[MARMAM] New publication: Dolphin-derived NETosis results in rapid Toxoplasma gondii tachyzoite ensnarement and different phenotypes of NETs (Imlau et al., 2019)

Michelle Imlau michelle.imlau at googlemail.com
Thu Nov 7 05:46:27 PST 2019


 Dear all,

We are happy to announce that the following paper is now published in
Developmental & Comparative Immunology.
We investigated the innate immune response of bottlenose dolphins against
apicomplexan parasite *Toxoplasma gondii*.


Michelle Imlau, Iván Conejeros, Tamara Muñoz-Caro, Ershun Zhou, Ulrich
Gärtner, Kerstin Ternes, Anja Taubert, Carlos Hermosilla,
Dolphin-derived NETosis results in rapid *Toxoplasma gondii *tachyzoite
ensnarement and different phenotypes of NETs, Developmental & Comparative
Immunology, Volume 103, 2020.

*Abstract*

*Toxoplasma gondii* is a cosmopolitan zoonotic parasite and nowadays
considered as an emerging neozoan pathogen in the marine environment.
Cetacean innate immune reactions against *T. gondii* stages have not yet
been investigated. Thus, *T. gondii* tachyzoites were utilized to trigger
neutrophil extracellular traps (NETs) in bottlenose dolphin (*Tursiops
truncatus*) polymorphonuclear neutrophils (PMN). Scanning electron
microscopy unveiled *T. gondii* tachyzoites as potent and rapid inducers of
cetacean-derived NETosis. Co-localization of extracellular chromatin with
global histones, granulocytic myeloperoxidase and neutrophil elastase
confirmed classical characteristics of NETosis. Interestingly, different
phenotypes of NETs were induced by tachyzoites resulting in spread, diffuse
and aggregated NET formation and moreover, ‘anchored’ and ‘cell free’
NETosis was also detected.

Current data indicate that cetacean-derived NETosis might represent an
early, ancient and well-conserved host innate defense mechanism that not
only acts against *T. gondii* but might also occur in response to other
closely related emerging apicomplexan parasites affecting marine cetaceans.
*Link to full text*: https://www.sciencedirect.com/science/article
<https://www.sciencedirect.com/science/article/pii/S0145305X19302964?utm_campaign=STMJ_75273_AUTH_SERV_PPUB&utm_medium=email&utm_dgroup=Email1Publishing&utm_acid=-800202876&SIS_ID=-1&dgcid=STMJ_75273_AUTH_SERV_PPUB&CMX_ID=&utm_in=DM601392&utm_source=AC_30>

Best regards,

Michelle

Michelle Imlau, med. vet.

Pathology Resident

Centre for Fish and Wildlife Health (FIWI)

Vetsuisse Faculty, University of Bern

michelle.imlau at vetsuisse.unibe.ch
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