[MARMAM] New publication: Immunotoxicity of Silver Nanoparticles (AgNPs) on cetacean leukocytes

Wen-Ta Li heerolee1104 at gmail.com
Thu Apr 5 08:20:45 PDT 2018

Dear all,

My co-authors and I are pleased to announce the new publication of the
following article in Scientific Reports.

Wen-Ta Li, Hui-Wen Chang, Wei-Cheng Yang, Chieh Lo, Lei-Ya Wang, Victor Fei
Pang, Meng-Hsien Chen & Chian-Ren Jeng

*Immunotoxicity of Silver Nanoparticles (AgNPs) on the Leukocytes of Common
Bottlenose Dolphins (Tursiops truncatus)*

Silver nanoparticles (AgNPs) have been extensively used and are considered
as an emerging contaminant in the ocean. The environmental contamination of
AgNPs is expected to increase greatly over time, and cetaceans, as the top
ocean predators, will suffer the negative impacts of AgNPs. In the present
study, we investigate the immunotoxicity of AgNPs on the leukocytes of
cetaceans using several methods, including cytomorphology, cytotoxicity,
and functional activity assays. The results reveal that 20 nm Citrate-AgNPs
(C-AgNP20) induce different cytomorphological alterations and intracellular
distributions in cetacean polymorphonuclear cells (cPMNs) and peripheral
blood mononuclear cells (cPBMCs). At high concentrations of C-AgNP20 (10
and 50 μg/ml), the time- and dose-dependent cytotoxicity in cPMNs and
cPBMCs involving apoptosis is demonstrated. C-AgNP20 at sub-lethal doses
(0.1 and 1 μg/ml) negatively affect the functional activities of cPMNs
(phagocytosis and respiratory burst) and cPBMCs (proliferative activity).
The current study presents the first evidence of the cytotoxicity and
immunotoxicity of AgNPs on the leukocytes of cetaceans and improves our
understanding of environmental safety concerning AgNPs. The dose-response
data of AgNPs on the leukocytes of cetaceans are invaluable for evaluating
the adverse health effects in cetaceans and for proposing a conservation
plan for marine mammals.

Free access to the article is available at

orPDF by email at this address heerolee1104 at gmail.com

or via researchgate (here


Wen-Ta Li

Wen-Ta Li, DVM, MS
PhD candidate/Veterinary Pathologist
Graduate Institute of Molecular and Comparative Pathobiology,
School of Veterinary Medicine, National Taiwan University
Veterinarian/Director, Taiwan Cetacean Society
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