[MARMAM] Alzheimer's disease in dolphins

William Rossiter rossiter at csiwhalesalive.org
Sun Nov 19 05:27:24 PST 2017

Alzheimer's disease in humans and other animals: A consequence of 
postreproductive life span and longevity rather than aging.

     Gunn-Moore, Danièlle et al.
     Alzheimer's & Dementia: The Journal of the Alzheimer's Association 
, Volume 0 , Issue 0 ,
     DOI: http://dx.doi.org/10.1016/j.jalz.2017.08.014


Alzheimer's disease and diabetes mellitus are linked by epidemiology, 
genetics, and molecular pathogenesis. They may also be linked by the 
remarkable observation that insulin signaling sets the limits on 
longevity. In worms, flies, and mice, disrupting insulin signaling 
increases life span leading to speculation that caloric restriction 
might extend life span in man. It is our contention that man is already 
a long-lived organism, specifically with a remarkably high postfertility 
life span, and that it is this that results in the prevalence of 
Alzheimer's disease and diabetes.

We review evidence for this hypothesis that carries specific predictions 
including that other animals with exceptionally long postreproductive 
life span will have increased risk of both diabetes and Alzheimer's disease.
Results and Conclusions

We present novel evidence that Dolphin, like man, an animal with 
exceptional longevity, might be one of the very few natural models of 
Alzheimer's disease.

Longevity, Insulin signaling, Alzheimer's pathology, Animal models, Tau, 
Amyloid, GSK-3

William Rossiter
Cetacean Society International
rossiter at csiwhalesalive.org

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