[MARMAM] New publication about lacaziosis-like disease in Tursiops truncatus from Brazil

Carlos Sacristan carlosvet.sac at gmail.com
Sat Jan 16 13:43:15 PST 2016

Dear Colleagues:

I am pleased to announce the publication of our research article about
Lacaziosis-like disease:

Sacristán C, Réssio RA, Castilho P, Fernandes NCCA, Costa-Silva S, Esperón
F, Daura-Jorge FG, Groch KR, Kolesnikovas CKM, Marigo J, Ott PH, Oliveira
LR, Sánchez-Sarmiento AM, Simões-Lopes PC, Catão-Dias JL (2015).
disease in Tursiops truncatus from Brazil: a histopathological and
immunohistochemical approach*. Dis Aquat Org 117:229-235

ABSTRACT: Cetacean lacaziosis-like disease or lobomycosis-like disease
(LLD) is a chronic skin condition caused by a non-cultivable yeast of the
order Onygenales, which also includes *Lacazia loboi*, as well as
brasiliensis*and *P. lutzii*, respectively responsible for lacaziosis and
paracoccidioidomycosis in humans. Complete identification and phylogenetic
classification of the LLD etiological agent still needs to be elucidated,
but preliminary phylogenetic analyses have shown a closer relationship of
the LLD agent to *Paracoccidioides* spp. than to *L. loboi*. Cases of LLD
in South American cetaceans based on photographic identification have been
reported; however, to date, only 3 histologically confirmed cases of LLD
have been described. We evaluated multiple tissue samples from 4 *Tursiops
truncatus* stranded in the states of Santa Catarina (n = 3) and Rio Grande
do Sul (n = 1), southern Brazil. Macroscopically, all animals presented
lesions consistent with LLD. Hematoxylin-eosin, periodic acid-Schiff,
Grocott’s methenamine silver, and Mayer’s mucicarmin stains were used for
histological evaluation. Microscopically, numerous refractile yeasts (4-9
µm in diameter) were observed in skin samples (4/4), and for the first time
in dolphins, also in a skeletal muscle abscess (1/4). Immunohistochemistry
using anti-*P. brasiliensis* glycoprotein gp43 as a primary antibody, which
is known to cross-react with *L. loboi* and the LLD agent, was performed
and results were positive in all 4 cases. We describe 3 new cases of LLD in
cetaceans based on histopathology and immunohistochemistry. This is the
first report of LLD in the muscle of cetaceans.


Articles available at link above or email: carlosvet.sac at gmail.com

Best regards

Carlos Sacristán

*Carlos Sacristán Yagüe*
DVM, MSc, PhD Candidate of Department of Pathology - VPT
Laboratory of Comparative Wildlife Pathology - LAPCOM
School of  Veterinary Medicine and Animal Sciences - FMVZ
University of São Paulo (Brazil)

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